Darwin Zaske, Pharm

Educational Objectives 1. Describe and calculate the dosage regimen of an aminoglycoside antibiotic for a patient with Gram negative sepsis. 2. Define the half-live of an aminoglycoside when given serum concentration time data. 3. Calculate the distribution volume of an aminoglycoside in a patient when given serum concentration time data. 4. Describe the physiologic variables which will change the pharmacokinetic parameters of an aminoglycoside in a patient who has Gram negative sepsis 5. Understand the clinical and pharmacokinetic reasons why aminoglycoside dosage regimens need to be individualized. 6. Describe the clinical importance of individualized dosage regimens have on patient outcomes. 7. Describe the most important time points when serum aminoglycoside samples should be obtained and used to determine pharmacokinetic parameters of halflife and distribution volume. 8. Describe the interpatient and the intrapatient variation with aminoglycosides and what clinical decisions can be applied to best ensure the desired patient outcome is attained.